Prospect of Sodium–Glucose Co-transporter 2 Inhibitors Combined With Insulin for the Treatment of Type 2 Diabetes
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چکیده
منابع مشابه
The effects of twelve weeks of combined exercises on GLP-1 and insulin resistance in women with type 2 diabetes
Introdution: The purpose of this study was to investigate the effect of twelve weeks of combined exercise with two patterns (aerobic-resistance and resistance-aerobic) on GLP-1 and insulin resistance in women with type 2 diabetes. Methods: In this practical and semi-experimental study, 42 women with type 2 diabetes were divided into three groups: aerobic-resistance group (n=15), resistance-aer...
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The low affinity sodium glucose cotransporter (SGLT2) plays a major role in physiology of glucose reabsorption from proximal part of kidney. Almost all glucose excreted through glomerular filtration, is reabsorbed via SGLT2 until blood glucose level reaches to its threshold value for glucose excretion i.e. ~180mg/dl. Increasing the glucose excretion by inhibiting the SGLT2 is the novel approach...
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BACKGROUND Sodium glucose co-transporter 2 (SGLT2) inhibitors are a new class of pharmacologic agents developed for the treatment of type 2 diabetes mellitus (T2DM). Their unique mechanism of action is independent of pancreatic beta-cell function or the degree of insulin resistance, giving these agents the potential for use in combination with any of the existing classes of glucose-lowering age...
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Introduction: Progranulin (PGRN) has been recently introduced as a new indicator of chronic inflammatory response in type 2 diabetes. The present study aimed to investigate the effect of combined training on serum levels of progranulin, glycosylated hemoglobin (HbA1c), and insulin resistance in overweight and obese women with type 2 diabetes. Materials and Methods: A total of 36 women were divi...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2020
ISSN: 1664-2392
DOI: 10.3389/fendo.2020.00190